I’ve been getting loads of emails a few new Xyngular product known as GLP-X. As the corporate web site says, ‘GLP-X is a premium complement method crafted from naturally sourced elements clinically studied to extend GLP-1 manufacturing.* (word asterisk that results in disclaimer that none of those claims have been evaluated by the FDA) It isn’t nearly managing weight—it’s about elevating your outcomes.’

As a registered dietitian, I’m all the time occupied with taking a more in-depth take a look at these types of corporations and their dietary supplements, as a result of all too typically, I discover that they sidestep the reality, and the analysis, within the curiosity of constructing gross sales.

This GLP-X evaluate examines the claims that Xyngular and its salespeople are making about this product, what GLP-1 is, and if we are able to actually ‘hack’ it with food regimen and dietary supplements to imitate the motion of GLP-1 agonists like Ozempic.

What’s GLP-1?

GLP-1, or glucagon-like peptide-1, is a peptide hormone that’s produced within the gut. Its job is to stimulate insulin (which brings glucose into cells, and is why GLP-1 medication have been initially authorised as drugs for diabetes), and inhibit glucagon (glucagon will increase blood sugar and fatty acids within the blood when meals isn’t current). 

GLP-1 additionally slows down gastrointestinal motility, which makes us really feel fuller for longer. Therefore, weight reduction (and certain, uncomfortable side effects like vomiting for some people who find themselves on GLP-1 agonist meds).

How do GLP-1 agonists like Ozempic work?

I wrote about Ozempic and different GLP-1 agonists for weight reduction right here

All of us have GLP-1 receptors in our physique. GLP-1 agonists are analog variations of our personal GLP-1 (comparable, however not precisely the identical), and so they work by binding to and activating our physique’s GLP-1 receptors. 

When this occurs, we see the identical results as those I described above: elevated insulin and decreased glucagon, and slowed motility with ensuing fullness. 

GLP-1 agonists have confirmed to be extraordinarily secure and efficient for weight reduction, however predictably, there are folks and corporations eager to make their very own buck by convincing others that ‘Large Pharma’ is the enemy and that ‘pure’ GLP-1 dietary supplements are so significantly better than precise medicine.

Take a look at this publish about Xyngular GLP-X:

The selling of Large Pharma conspiracy theories whereas spouting the Attraction to Nature fallacy (pure is best! OMG SYNTHETIC MEDICATION!) is a traditional gross sales tactic that’s sadly turning into extra frequent, particularly amongst multi-level advertising salespeople. It’s fallacious, deceptive, and simply plain opportunistic, which is the principle purpose why, as a dietitian, I selected to put in writing this publish. 

Everybody ought to concentrate on this form of factor. Oh, and likewise, this complement is NOT ‘backed by 3 medical trials.’ Not even shut. See how MLM salespeople can principally say something to promote product?

Horrible. Additionally: a 30 day provide of GLP-X prices $75 USD. Not precisely what I’d name ‘reasonably priced.’

Can we improve our GLP-1 naturally utilizing meals and dietary supplements?

Let’s begin with the meals a part of the equation.

There are specific meals which might be identified to extend ranges of GLP-1 in our our bodies. Excessive-fibre grains, eggs, nuts, and avocado are amongst them, in line with this 2016 evaluate.

Specifically, mono and polyunsaturated fat, proteins, and fermentable fibre (fermentation within the intestine to short-chain fatty acids will increase GLP-1 ranges) from grains, legumes, and a few fruits like apples and inexperienced bananas. Analysis on this space is fairly hit and miss although, and as ordinary I’m reluctant to take animal research and extrapolate them to people. 

It’s secure to say that even when we eat meals that improve GLP-1 ranges in our our bodies, this doesn’t even method the effectiveness of GLP-1 agonists for weight reduction. 

Let’s take into consideration this for a second – we’ve had entry to those meals perpetually. Would we impulsively uncover that they’ve these magical weight reduction powers past what we already know?

I extremely doubt it.

My suggestions listed here are the identical as all the time: plenty of fibre, sufficient protein, wholesome fat. Can’t lose. 

So far as dietary supplements, as with meals, there have been none which have proven the extent of effectiveness of GLP-1 agonist drugs. 

If a complement does have comparable efficacy to precise GLP-1 agonist meds for weight reduction, it doubtless won’t be offered by a multi-level advertising firm. Will probably be regulated by the FDA and used as a legit remedy.

What’s Xyngular?

Xyngular is an MLM firm that sells diet merchandise. 

I did an up to date Xyngular evaluate on my web site in 2020, and I doubt a lot has modified with the corporate since then.

Right here’s a few of Xyngular’s product lineup. Typical fats burners, ‘craving controllers, and intestine well being boosters.

Most if not all diet MLM corporations make use of the identical methods to make gross sales (and that is on no account an exhaustive checklist):

Large claims which might be unimaginable to again up

Lack of oversight of their salespeoples’ social media posts

Poor or no analysis on their merchandise

Fixed upsells

Benefiting from girls who wish to make an earnings

I wrote about my points with MLMs and their coaches right here, however let’s simply say that Xyngular is unremarkable amongst its MLM friends. 

What’s Xyngular GLP-X?

Xyngular GLP-X is a complement that’s being marketed as a substitute for GLP-1 agonist drugs for weight reduction and ‘GLP-1 help.’ What’s that, anyhow? I wasn’t conscious that our GLP-1 wanted to be supported.

Made up time period with imprecise well being declare = crimson flag.

It comes with the entire ordinary bells and whistles of a newly launched MLM product – full courtroom press gross sales throughout social media by the Xyngular salespeople, cute little graphics that inform us principally nothing scientific, and naturally, magical and fantastical guarantees that this little bottle accommodates the reply to all of our issues…no prescription required!

Xyngular GLP-X elements

Herbs and chromium and proprietary blends, oh my! Right here’s what GLP-X has in it:

Carb administration mix

This proprietary mix accommodates Eriomin and berberine. That is the precise mix in Xyngular GLP-X that the corporate states will increase GLP-1. 

Eriomin is a patented citrus bioflavonoid nutraceutical complement. A each day dose (2 capsules) of GLP-X accommodates 250mg of Eriomin.

The place have I heard about Eriomin earlier than? Oh, proper! The Glucose Goddess’s subsequent complement, Anti-Spike, accommodates it as effectively. I wrote all about Anti-Spike right here, and simply to repeat what I mentioned about Eriomin in that case, there are two research about this citrus extract and blood glucose. Each are comparatively unremarkable by way of blood sugar discount. 

One of many research, executed in 2019, noticed a 15% rise in GLP-1 with dosages of 200-800 mg of Eriomin over 12 weeks. Nevertheless, researchers discovered it had no impact on physique weight, BMI, lean mass, fats mass, fats proportion, and hip waist ratio. 

The 12-week 2022 research that includes Eriomin discovered a 17% rise in GLP-1 with 200 mg a day of the ingredient. Nevertheless, physique weight and BMI remained unchanged. 

You’ve in all probability heard me bang on and on concerning the significance of ‘medical relevance,’ and that is the proper time to indicate you what I imply. 

Within the above research, we see that GLP-1 ranges have been certainly increased after supplementation with Eriomin. This sounds nice, till you’re wanting to make use of this ingredient to advertise weight reduction. As a result of regardless that there was a big change within the research topics’ GLP-1, nothing actually occurred to their weight whereas these ranges have been elevated. 

It principally didn’t change a factor round weight. 

Repeat after me: it might be ‘important,’ however that doesn’t imply it’s clinically related to us!

So far as Berberine, we do know that it has optimistic results for rising GLP-1 and for lowering blood glucose in folks with diabetes. Nevertheless, berberine doesn’t decrease blood glucose by rising GLP-1 within the physique; it promotes insulin secretion and improves glucose regulation, amongst different mechanisms.

Once more, medical relevance of this ingredient for GLP-1-related weight reduction? In all probability none. 

GLP-X additionally accommodates a proprietary ‘water stability mix,’ in any other case referred to as a diuretic. Peeing out fluids doesn’t equal ‘weight reduction.’ Or, ought to I say, ‘fats loss.’ 

Then there’s the proprietary ‘urge for food help mix,’ which accommodates the standard suspects: inexperienced espresso bean, 5-ATP, and phytosterols, none of which have ever been confirmed to facilitate important weight reduction in people.

Even so, a ton of multi-level marketed merchandise proceed to place these elements of their weight reduction merchandise. Sadly, science doesn’t care how onerous you would like for one thing to work so your product may be the ‘subsequent smartest thing.’

A phrase about proprietary blends: I like to recommend not buying merchandise that include proprietary blends. These are principally smokescreens that corporations can cover behind in order that they don’t should reveal the precise quantities of elements which might be of their merchandise. It could possibly be somewhat, it could possibly be loads. It could possibly be the efficient dose (assuming any of the elements are efficient in any respect), it could possibly be much less. For GLP-X, for instance, we do not know how a lot Berberine or Eriomin is in every capsule. It’s a roulette wheel that I don’t suggest spinning together with your pockets or your well being.

GLP-X has two extra elements which might be equally underwhelming for weight reduction and results on GLP-1: chromium and magnesium.

Nothing about these two minerals will increase weight reduction or GLP-1. That’s all.

What? However I believed GLP-X is ‘backed by 3 medical trials’?

The truth that Xyngular and its salespeople can say that the elements on this product are ‘clinically studied to extend GLP-1’ makes most individuals assume that 1. GLP-X itself has optimistic research behind it (it doesn’t) and a pair of. the elements ship clinically related and significant outcomes for GLP-1 resulting in weight reduction. 

Nope to all of that, nevertheless it’s a advertising tactic I see actually daily with dietary supplements. It’s deceptive and it’s disappointing. 

Does Xyngular GLP-X work?

Whereas a number of the elements in Xyngular GLP-X have been proven to enhance blood glucose administration in some folks, there isn’t a analysis to indicate that the GLP-X complement itself really does what Xyngular claims it does.

There are many GLP-X testimonials, however these are simply faked, and guess what? MLM coaches like to publish them, however conveniently neglect to publish the not-so-glowing opinions, too.

Why are we so determined to look a sure manner, that we belief our well being to those corporations and their salespeople, most of whom have zero related well being coaching and who don’t care about our well being, solely their gross sales? Please don’t.

So far as ‘pure’ GLP-1 dietary supplements, these are extra fable than truth. Simply because one thing will increase our GLP-1 ranges doesn’t imply that this results in the burden loss results we’d see with GLP-1 agonist drugs. Actually, the analysis is fairly clear that in most (if not all) instances, it doesn’t.

Save your $75.